At least three people have been killed after a shooting at a US university.

A manhunt was launched for the attacker at Michigan State University after he fled on foot and was described as a short black male in a cap, red shoes and a jean jacket.

He later died from an apparent self-inflicted gunshot wound, police said.

As well as the fatalities, police said five people were taken to hospital, some in a life-threatening condition.

The incident began at 8.18pm local time when shots were fired at Berkey Hall on the East Lansing campus.

Students and staff were told to “secure-in-place immediately” as officers responded to multiple 911 calls.

Police said the gunman also opened fire at the nearby university union and was last seen leaving the building on foot.

Large numbers are likely to have been locked down as about 50,000 people attend the campus – which also hosts evening classes.

About four hours after the initial alert, police said the gunman had been found dead off-campus with an apparent self-inflicted gunshot wound after “contact” with law enforcement.

Chris Rozman, from Michigan State University Police, said “numerous” officers had responded within minutes and gave first aid at both shooting locations.

Two of the victims died at Berkey Hall and the other at the MSU union, said Mr Rozman.

He told reporters that “hundreds” of police and law enforcement personnel had been involved with hunting for the gunman.

The campus is about 90 miles northwest of Detroit.

Lisa McClain, US representative for Michigan, tweeted earlier: “There are reports of an active shooting on campus at Michigan State University.

“If you are there, police instructions are to Run, Hide, Fight. I am praying for all Spartans right now.”